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Melanocortin Biology 2 min read Updated 9 July 2026

What Is Melanotan 2?

Melanotan 2

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Melanotan 2

Research peptide · 10mg

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Melanotan 2 is a synthetic peptide studied within melanocortin research. It is described in the scientific literature as an analogue of alpha-melanocyte-stimulating hormone (alpha-MSH), a naturally occurring signalling peptide.

Its structure makes it a useful tool for laboratory investigation of the melanocortin receptor family and the receptor-signalling pathways associated with it.

Research Classification

Compound Name
Melanotan 2
Category
Melanocortin
Research Area
Melanocortin receptor & pigmentation signalling
Storage Conditions
Store at 2–8°C, protected from light

Biological Pathways

  • Melanocortin receptor family — a group of G-protein coupled receptors studied as targets for alpha-MSH and its analogues.
  • MC1R signalling — the melanocortin-1 receptor is studied in the context of pigmentation biology and melanin-related cellular signalling.
  • Peptide receptor signalling — research examines how a synthetic analogue engages the same receptor systems as the endogenous peptide.

Mechanism Of Interest

Melanotan 2 is studied as an analogue of alpha-MSH, the endogenous peptide that activates melanocortin receptors.

Research focuses on its interaction with the melanocortin receptor family, a group of receptors involved in a range of signalling functions.

MC1R signalling is a primary area of academic interest, as the melanocortin-1 receptor has a documented role in pigmentation-related cellular signalling.

Comparative work studies how the synthetic analogue behaves relative to the naturally occurring alpha-MSH peptide.

Why Researchers Are Interested

  • It serves as a stable analogue for studying melanocortin receptor activity.
  • The melanocortin system is an active area of cellular and receptor biology research.
  • It allows comparison between synthetic analogues and the naturally occurring alpha-MSH peptide.

Areas Of Ongoing Research

Melanocortin receptor binding and activityMC1R and pigmentation signalling pathwaysAlpha-MSH analogue structure–function studiesComparative peptide pharmacology

Storage Information

  • Store lyophilised material at 2–8°C, protected from light and moisture.
  • Keep reconstituted material refrigerated and handle under standard laboratory conditions.
  • Minimise freeze–thaw cycles to maintain peptide stability.

Frequently Asked Questions

What is an alpha-MSH analogue?+

It is a synthetic molecule designed to resemble alpha-melanocyte-stimulating hormone, a naturally occurring signalling peptide studied in melanocortin research.

What pathways is Melanotan 2 associated with?+

The literature associates it with the melanocortin receptor family, MC1R signalling and pigmentation-related cellular signalling.

How is Melanotan 2 stored?+

Lyophilised peptide is typically stored at 2–8°C, protected from light, with freeze–thaw cycles minimised.

References

  • Melanocortin receptor family and alpha-MSH biology (review literature)

    Peer-reviewed receptor biology reviews (PubMed-indexed)

  • MC1R signalling and pigmentation biology

    Published cell-signalling literature

  • Melanocortin receptor sequence records

    UniProt public database

References point to reputable, publicly available scientific literature and databases for educational context. They are provided for background reading only.

For laboratory research use only. Not for human or animal consumption.

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Melanotan 2

Research peptide · 10mg · Research use only

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